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ImmuniTea – Get the Tea For Life





[Legal Disclaimer: I am not a doctor and none of this should be construed as medical advice. Always consult a medical doctor first before beginning any treatment.]

Infection is the leading killer today in the United States. Every day millions of pigs are given antibiotics whether they are sick or not. And every day the bacteria become more resistent. Every doctor knows we are facing a crisis where our antibiotics that work are becoming fewer and fewer and more dangerous. The last resort treatments administered in hospitals by IV may defeat the infection but kill your liver and kidneys in the process. They are called FLUOROQUINOLONES and they are made from, you guessed it – FLUORIDE! Drugs like Cipro or Levaquin but also Avelox or generics ciprofloxacin, levofloxacin, and moxifloxacin, or others. “The adverse effects from these antibiotics are often as severely neurological as the adverse effects of Gardasil and other vaccinations” – Paul Fassa, The Dangers of fluoride-based Antibiotics

There is an alternative. Immuni-Tea is a researched product containing a mix of herbs which have been traditionally been used to fight infection and improve health.

I was sick and dying. The doctors put me on four different antibiotics of the strongest stuff they had. I took one of them for two months. They made me sick to my stomach, but not better. I switched to chinese herbals and began to test what seemed to work or make a difference. After three years of being sick with infection slowly I began to heal. Healing with herbs takes time even months it is not a magic overnight effect. These herbs have been researched in China for centuries and around the world by people struggling to find answers to difficult ailments like lyme disease. Some herbs boost immune strength while others clear illness and blood. Some herbs help to move bile. This is why an assortment of herbs is needed to fight from all directions. They may have funny names like “Stinky Cat Herb” and it may smell and taste like nothing on earth you’ve ever had before, these are strong and after drinking your tea it’s best to rest. This blend actually is formulated to taste moderate and not be difficult to drink but some of it’s components alone can be quite unpleasant.

Take once or twice a week to promote your general health. When sick, take daily or twice daily mornings and evenings. It may also be used as a poultice directly on the skin then covered with a wrap. Do not take more than 12oz of tea a day produced from a maximum of two tea bags.

Unlike regular tea, immuni-tea takes a bit longer to prepare. YOU MUST FOLLOW ALL DIRECTIONS EXACTLY

Ideal preparation: In a small sauce pan bring 12oz of water to a boil. Add the immuni-tea bag then reduce heat to a low simmer for five minutes. Then turn off, cover, and rest for 1-2 hours. (Note: 30 minutes will produce acceptable tea). This produces two six ounce doses. Drink one full glass of water afterwards then rest for at least one hour.

Easy preparation: Simply drop a tea bag into a large mug. Pour rapidly boiling water over it until mug is half full. Cover the mug with a plate and let rest for 10-60 minutes. Drink over the course of one or two sittings. Drink one full glass of water afterwards then rest for at least one hour.

Prepare as Poultice for Direct Application to Skin: Wet tea bag slightly. Let sit ten minutes. Wet tea bag slight again and apply. You may dab areas or apply and wrap with gauze to keep in contact with skin.

Cautions: Do not use by pregnant women, children under 8 years of age should take 1/4 teabag in 8oz water no more than once a day, people with spleen disorders or chronic digestive weakness. Do not continue if you have any bad side effects especially digestive or vomiting. Not for use in children under 4 years of age. Do not use without consulting your doctor first.

Ingredients: Chuan Xin Lian (Andrographis Paniculata), Dang Shen (Codonopsis Root), Elderberry, Gan Cao (Chinese Licorice), Ginseng, Huang Lian (Coptis Japonica), Olive Leaf Extract, Uncaria Tomentosa (Cats Claw Bark), Yu Xing Cao (Houttuynia), natural flavors

Buy Immunitea

Drug Interactions:

Cytochrome P450 substrates
Andrographis extract inhibits 1A2, 2C9, 3A4 (37); some compounds of Andrographis were shown to induce CYP1A1 (39). These two properties can affect the intracellular concentration of drugs metabolized by these enzymes.
Anticoagulants and antiplatelet drugs
Data from animal studies indicate possible inhibition of platelet aggregation (34) (35). But an animal study showed that andrographis extract does not interact with warfarin when used concomitantly (38). Patients taking anticoagulant or antiplatelet medications should use andrographis products with caution.
Chemotherapy drugs
Andrographolide may have antioxidant effects (21). This can interfere with the actions of some chemotherapy drugs.
Blood pressure lowering drugs
Andrographis may have additive hypotensive effect

Cytochrome P450 substrates: Huanglian inhibits CYP2D6 (11)CYP2D6, CYP2C9, and CYP3A4 (13) and can affect drugs metabolized by these enzymes. However, prolonged use of huanglian can induce CYP3A4 by activating pregnane X receptor (12) .

Cats Claw
Cytochrome P450 substrates: Cat’s claw inhibits CYP3A4 in vitro indicating that it may increase the serum levels of drugs such as nonnucleoside reverse-transcriptase inhibitors, cyclosporine, and some benzodiazepines (8).
Protease Inhibitors: Cat’s claw was shown to increase the serum concentrations of atazanavir, ritonavir and saquinavir (15).

Olive Leaf:
Antihypertensive drugs: May increase the blood pressure lowering effect (6).
Insulin and Antidiabetic drugs: May increase the hypoglycemic effect(2).
Chemotherapy drugs: May interfere with the actions of certain chemotherapy drugs due to its antioxidant effects.

Insulin and sulfonylureas: Panax ginseng may increase the hypoglycemic effect of insulin and sulfonylureas (5).
Anticoagulants: Panax ginseng may antagonize the effects of anticoagulants (6) (7) (8).
Monoamine oxidase inhibitors (MAOIs): Panax ginseng may cause manic-like symptoms when combined with MAOIs (9).
Imatinib: Panax ginseng may increase risk of hepatotoxicity (24).
Cytochrome P450 (CYP) 3A4 substrates: Certain ginsenosides can induce CYP3A4 and may increase the clearance of substrate drugs (28) (29).
Raltegravir: Elevated plasma levels of raltegravir, an antiretroviral drug, were reported in a patient following concurrent use of raltegravir and ginseng (32).

Other Medical Issues & Contraindications:
· should be discontinued at least one week before surgery
· Panax ginseng may have estrogenic activity. Patients with hormone-sensitive cancer should avoid taking it
· may cause renal failure in patients with systemic lupus erythematosus (cats claw)



Paul Fassa,

Formulations containing standardized extracts of andrographis are also marketed in the West as dietary supplements for cold and flu. Kan Jang, a standardized extract of Andrographis paniculata and Eleutherococcus senticosus, has been studied in manufacturer-sponsored clinical trials for relief of respiratory symptoms from cold and flu (1) (2) (3) (4).
An Andrographis extract was effective in treating the symptoms of upper respiratory infection (5)and another study found it as effective as mesalamine in treating ulcerative colitis (6). Andrographis extract also reduced rheumatoid factors and relieved rheumatoid arthritis symptoms (7)and has been studied in an early phase trial for male fertility (8).

Tang T. et al. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis – a double-blind comparison with sustained release mesalazine. Aliment Pharmacol Ther. 2011 Jan;33(2):194-202.
This was an 8-week randomized, double-blind, parallel group study that compared the efficacy of an Andrographis extract (HMPL-04) to slow-release mesalamine granules in 120 patients with mild-to-moderate active ulcerative colitis. Assessments of clinical response were made at baseline and every 2 weeks, and colonoscopy was performed at baseline and at 8 weeks. Clinical response was defined as remission (no symptoms), partial remission (50% reduction in symptoms), or improvement (25% reduction in symptoms). Secondary endpoints were based on colonoscopy findings of inflammation and mucosal appearance, and histological improvement at biopsy. At week 8, remission was observed in 74% (p<0.001) and 28% of the HMPL-04 treated patients (n=60), and 71% (p<0.001) and 24% of the mesalamine-treated patients (n=60), respectively. But the differences were not statistically significant.
The authors concluded that HMPL-04 may be an effective alternative to mesalamine treatment for ulcerative colitis.

Saxena RC, et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010 Mar;17(3-4):178-85.
This randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy of an Andrographis extract in patients with uncomplicated upper respiratory tract infection (URTI). Patients (n=223) were randomized into groups to receive either Andrographis extract (n=112) or placebo (n=111). Patients self-evaluated and scored symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise/fatigue, and sleep disturbances using a Visual Analogue Scale. For both groups, mean symptom scores showed a significantly decreasing trend (p<0.05) from day 1 to 3, but from day 3 to 5, most of the symptoms in the placebo group either remained unchanged or worsened. However, in the Andrographis extract group, all symptoms (except earache) continued to show a significantly decreasing trend (p<0.05) from days 3 to 5. By day 5, improvement in overall symptom scores in the Andrographis extract group was significantly better than placebo (p<0.05), a decrease of 155.49+7.26 points vs 73.52+6.98 points, respectively. A few minor adverse effects were observed, with no significant difference between groups. The investigators concluded that Andrographis extract was effective in reducing the symptoms of URTI.

Burgos RA, et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009 Aug;28(8):931-46.
This randomized, double-blind, placebo-controlled trial investigated the efficacy of Andrographis extract tablets (ParactinÒ) in patients (n=60) with active rheumatoid arthritis (RA). After a 2 week washout period, patients received either Andrographis extract (n=30) or placebo (n=30) for 14 weeks. The primary outcome measure was pain intensity, evaluated by a horizontal visual analog pain scale (VAPS). By week 14, joint pain intensity decreased in the treatment group, however this difference was not statistically significant compared to placebo. However, by week 1, the treatment group experienced a statistically significant decrease in other RA symptoms (tender joints [p=0.001], number of swollen joints [p=0.02], total grade of swollen joints [p=0.010], number of tender joints [p=0.033], total grade of swollen joints [p=0.01], total grade of tender joints [p=0.002], and health assessment quality survey [p<0.001]) compared to placebo. A significant reduction in rheumatoid factors IgA (p=0.101) and C4, (p=0.031) was also observed in the treatment group compared to placebo. The authors concluded that Andrographis may be a useful complementary treatment for RA, however a longer and larger trial is needed to confirm these results.

Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res 2004;18(1):47-53.
A three arm study was conducted comparing Kan Jang preparation with Immunal, an Echinacea-based preparation, as adjuvants to a standard regimen of warm drinks, mouth gargles and paracetamol prn in children aged 4 to 11 suffering from the common cold over 10 days. 130 children were randomized to receive either standard treatment, or standard treatment with either Kan Jang or Immunal. Adjuvant treatment with Kan Jang was more effective than Immunal. Cold symptoms were less severe in the Kan Jang group, particularly in the amount of nasal secretion and congestion reported. Kan Jang accelerated recovery time compared to Immunal which did not demonstrate the same efficacy. There was less use of standard medication in the Kan Jang group, and treatment was well tolerated.

Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res 2004;18(1):47-53.
Kulichenko LL, Kireyeva LV, Malyshkina EN, Wikman G. A randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd. J Herb Pharmacother 2003;3(1):77-93.
Melchior J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 2000;7(5):341-350.
Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9(7):589-597.
Saxena RC, Singh R, Kumar P, et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010 Mar;17(3- 4):178-85.
Tang T, Targan SR, Li ZS, et al. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis – a double-blind comparison with sustained release mesalazine. Aliment Pharmacol Ther. 2011 Jan;33(2):194-202.
Burgos RA, Hancke JL, Bertoglio JC, et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009 Aug;28(8):931-46.
Mkrtchyan A, Panosyan V, Panossian A, et al. Aphase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects. Phytomedicine 2005;12(6-7):403-409.
Samy RP, Thwin MM, Gopalakrishnakone P, Ignacimuthu S. Ethnobotanical survey of folk plants for the treatment of snakebites in Southern part of Tamilnadu, India. J Ethnopharmacol 2007.
Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14(5):333-338.
Kligler B, Ulbricht C, Basch E, et al. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standard research collaboration. Explore (NY) 2006;2(1):25-29.
Chun JY, Tummala R, Nadiminty N, et al. Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer growth. Genes Cancer. 2010 August 1; 1(8): 868-876.
Shi MD, Lin HH, Chiang TA, et al. Andrographolide could inhibit human colorectal carcinoma Lovo cells migration and invasion via down- regulation of MMP-7 expression. Chem Biol Interact. 2009 Aug 14;180(3):344-52.
Chao HP, Kuo CD, Chiu JH, et al. Andrographolide exhibits anti- invasive activity against colon cancer cells via inhibition of MMP2 activity. Planta Med. 2010 Nov;76(16):1827-33.
Lee YC, Lin HH, Hsu CH, et al. Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. Eur J Pharmacol. 2010 Apr 25;632(1- 3):23-32.
Ji L, Liu T, Liu J, et al. Andrographolide inhibits human hepatoma-derived Hep3B cell growth through the activation of c-Jun N-terminal kinase. Planta Med 2007;73(13):1397-1401.
Zhou J, Zhang S, Ong CN, Shen HM. Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochem Pharmacol 2006;72(2):132-144.
Jiang CG, Li JB, Liu FR, et al. Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression. Anticancer Res 2007;27(4B):2439-2447.
Sheeja K, Kuttan G. Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide. Immunopharmacol Immunotoxicol 2007;29(1):81-93.
Zhou J, Ong CN, Hur GM, et al. Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochem Pharmacol. 2010 May 1;79(9):1242-50.
Shen YC, Chen CF, Chiou WF. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br J Pharmacol. Jan 2002;135(2):399-406.
Wiart C, Kumar K, Yusof MY, et al. Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1. Phytother Res 2005;19(12):1069-1070.
Singha PK, Roy S, Dey S. Antimicrobial activity of Andrographis paniculata. Fitoterapia 2003;74(7-8):692-694.
Dua VK, Ojha VP, Roy R, et al. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J Ethnopharmacol 2004;95(2-3):247-251.
Burgos RA, Seguel K, Perez M, et al. Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta Med 2005;71(5):429-434.
Liu J, Wang ZT, Ji LL, Ge BX. Inhibitory effects of neoandrographolide on nitric oxide and prostaglandin E2 production in LPS-stimulated murine macrophage. Mol Cell Biochem 2007;298(1-2):49-57.
Verma N, Vinayak M. Antioxidant action of Andrographis paniculata on lymphoma. Mol Biol Rep. Sep 5 2007.
Sheeja K, Guruvayoorappan C, Kuttan G. Antiangiogenic activity of Andrographis paniculata extract and andrographolide. Int Immunopharmacol 2007;7(2):211-221.
Sheeja K, Kuttan G. Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity. Integr Cancer Ther 2006;5(3):244-251.
Sheeja K, Kuttan G. Ameliorating effects of Andrographis paniculata extract against cyclophosphamide-induced toxicity in mice. Asian Pac J Cancer Prev 2006;7(4):609-614.
Jaruchotikamol A, Jarukamjorn K, Sirisangtrakul W, et al. Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes. Toxicol Appl Pharmacol 2007;224(2):156-162.
Yoopan N, Thisoda P, Rangkadilok N, et al. Cardiovascular effects of 14-deoxy-11,12-didehydroandrographolide and Andrographis paniculata extracts. Planta Med 2007;73(6):503-511.
Burgos RA, Aguila MJ, Santiesteban ET, et al. Andrographis paniculata (Ness) induces relaxation of uterus by blocking voltage operated calcium channels and inhibits Ca(+2) influx.Phytother Res 2001;15(3):235-239.
Thisoda P, Rangkadilok N, Pholphana N, et al. Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation. Eur J Pharmacol 2006;553(1-3):39-45.
Burgos RA, Hidalgo MA, Monsalve J, et al. 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. Planta Med 2005;71(7):604-608.
Panossian A, Hovhannisyan A, Mamikonyan G, et al. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine 2000;7(5):351-364.
Pekthong D, Martin H, Abadie C, et al. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide. J Ethnopharmacol 2007.
Hovhannisyan AS, Abrahamyan H, Gabrielyan ES, Panossian AG. The effect of Kan Jang extract on the pharmacokinetics and pharmacodynamics of warfarin in rats. Phytomedicine 2006;13(5):318-323.
Chatuphonprasert W, Remsungnen T, Nemoto N, Jarukamjorn K. Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes. Toxicol In Vitro. 2011 Dec;25(8):1757-63.

Cats Claw
Cat’s claw demonstrated anticancer effects against several cancer cell lines (6) (7) (17) (18). However, no human studies have been conducted to evaluate its efficacy.
Reported adverse reactions include hypotension and diarrhea. An additive effect with anticoagulants or hypotensives is possible (8).

Riva L, et al. The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Res 2001;21:2457-61.
Sandoval M, et al. Cat’s claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-8.
Sandoval M, et al. Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine 2002;9:325-37.
Sheng Y, Bryngelsson C, Pero R. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol 2000;69:115-26.
Reis SR, Valente LM, Sampaio AL, et al. Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2. Int Immunopharmacol. Mar 2008;8(3):468-476.
Garcia Prado E, Garcia Gimenez MD, De la Puerta Vazquez R, Espartero Sanchez JL, Saenz Rodriguez MT. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine. Apr 2007;14(4):280-284.
Pilarski R, Poczekaj-Kostrzewska M, Ciesiolka D, Szyfter K, Gulewicz K. Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells. Pharmacol Rep. Sep-Oct 2007;59(5):565-572.
Scott GN, Elmer GW. Update on natural product-drug interactions. Am J Health-Syst Pharm 2002;59:339-47.
Hemingway SR, Phillipson JD. Proceedings: alkaloids from south American species of Uncaria (Rubiaceae). J Pharm Pharmacol 1974;26(suppl):113.
Wirth C, et al. Pharmacologically active procyanidines from the bark of Uncaria tomentose. Phytomedicine 1997;4:265-6.
Aquino R, et al. Plant metabolites: New compounds and anti-inflammatory activity of Uncaria tomentosa. J Nat Prod 1991;54:453-9.
Rizzi R, et al. Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmacol 1993;38:63-77.
Sheng Y, et al. DNA repair of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8:275-82.
Hilepo JN, et al. Acute renal failure caused by ‘cat’s claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77:361.
López Galera RM, Ribera Pascuet E, et al. Interaction between cat’s claw and protease inhibitors atazanavir, ritonavir and saquinavir. Eur J Clin Pharmacol. 2008 Dec;64(12):1235-6.
Cosentino C, Torres L. Reversible worsening of Parkinson disease motor symptoms after oral intake of Uncaria tomentosa (cat’s claw). Clin Neuropharmacol. 2008 Sep-Oct;31(5):293-4.
Rinner B, Li ZX, Haas H, et al. Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer Res. 2009 Nov;29(11):4519-28.
García Giménez D, García Prado E, Sáenz Rodríguez T, et al. Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing sarcoma and breast cancer cell lines. Planta Med. 2010 Feb;76(2):133-6.

Huang Lian (Berbine)
Huang KC. The Pharmacology of Chinese Herbs, 2nd ed. New York: CRC Press; 1999.
Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med 1995;61:414-8.
Lin HL, et al. Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells. Cancer 1999;85:1937-42.
Brinker F. Herb Contraindications and Drug Interactions, 3rd ed. Sandy (OR): Eclectic Medical Publications; 2001.
Li XK, et al. Huanglian, A Chinese herbal extract, inhibits cell growth by suppressing the expression of cyclin B1 and inhibiting CDC2 kinase activity in human cancer cells. Mol Pharmacol 2000;58:1287-93.
Wang S, et al. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci. 2004 Apr 2;74(20):2467-78.
Kang JX, Liu J, Wang J, et al. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis 2005;26(11):1934-9.
Auyeung KK, Ko JK. Coptis chinensis inhibits hepatocellular carcinoma cell growth through nonsteroidal anti-inflammatory drug-activated gene activation. Int J Mol Med. 2009 Oct;24(4):571-7.
Feng Y, Siu KY, Ye X, et al. Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med. 2010 Sep 18;5:33.
Xia X, Yan J, Shen Y, et al. Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS One. 2011 Feb 3;6(2):e16556.
Han YL, Yu HL, Li D, et al. In Vitro Inhibition of Huanglian [Rhizoma coptidis (L.)] and its Six Active Alkaloids on Six Cytochrome P450 Isoforms in Human Liver Microsomes. Phytother Res. 2011 Mar 21. [Epub ahead of print]
Yu C, Chai X, Yu L, Chen S, Zeng S. Identification of novel pregnane X receptor activators from traditional Chinese medicines. J Ethnopharmacol. 2011 Jun 14;136(1):137-43.
Guo Y, Chen Y, Tan ZR, et al. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol. 2012 Feb;68(2):213-7.
Zhang Q, Piao XL, Piao XS, Lu T, Wang D, Kim SW. Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides. Food Chem Toxicol. 2011 Jan;49(1):61-9.
Zhang B, Cao A, Zhou J, Hu Z, Wu D.Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus. J Pharm Pharmacol. 2012 Mar;64(3):413-9.

Olive Leaf

Montilla MP, Agil A, Navarro MC, Jimenez MI, Garcia-Granados A, Parra A et al. Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. Planta Med 2003;69:472-4.
Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. Hypoglycemic activity of olive leaf. Planta Med 1992;58:513-5.
Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses 2003;46:132-6.
Lee-Huang S, Zhang L, Huang PL, Chang YT, Huang PL. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem.Biophys.Res Commun. 2003;307:1029-37.
PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 1998.
Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. Journal of Ethnopharmacology.Vol.84(2-3)()(pp 299-305), 2003. 2003;299-305.
Pasquale RD, Monforte A, Trozzi A, Raccuia S, Tommasini S, Ragusa S. Effects of leaves and shoot of Olea europaea L. and oleuropien on experimental hypercholesterolemia in rat. Plantes Med Phytother 1991;25:134-40.
Horn C. Olive leaf to fight infection. Natural Health 2000;30:40.
Zarzuelo A, Duarte J, Jimenez J, Gonzalez M, Utrilla MP. Vasodilator effect of olive leaf. Planta Med 1991;57:417-9.
Pieroni A, Heimler D, Pieters L, van Poel B, Vlietinck AJ. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie 1996;51:765-8.
Brinker F. Herb Contraindications And Drug Interactions. Sandy, OR: Eclectic Medical Publications, 2001.
Liccardi G, D’Amato M, D’Amato G. Oleaceae pollinosis: a review. Int Arch.Allergy Immunol. 1996;111:210-7.
Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009 Nov;139(11):2079-86.
Anter J, Fernández-Bedmar Z, Villatoro-Pulido M, et al. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 May 20. [Epub ahead of print].
Mijatovic SA, Timotijevic GS, Miljkovic DM, et al. Multiple antimelanoma potential of dry olive leaf extract. Int J Cancer. 2011 Apr 15;128(8):1955-65.
Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, et al. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res. 2008 Sep;22(9):1239-42.
Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine. 2011 Feb 15;18(4):251-8.
Abaza L, Talorete TP, Yamada P, et al. Induction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian gerboui olive leaf extract. Biosci Biotechnol Biochem. 2007 May;71(5):1306-12.
Anter J, Fernández-Bedmar Z, Villatoro-Pulido M, et a. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 Aug 16;723(2):165-70.
Kaeidi A, Esmaeili-Mahani S, Sheibani V, et al. Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studies. J Ethnopharmacol. 2011 Jun 14;136(1):188-96.
Esmaeili-Mahani S, Rezaeezadeh-Roukerd M, Esmaeilpour K, et al. Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats. J Ethnopharmacol. 2010 Oct 28;132(1):200-5.
Panax Ginseng
Cui Y, Shu XO, Gao YT, et al. Association of ginseng use with survival and quality of life among breast cancer patients. Am J Epidemiol 2006;163:645-53.
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He BC, Gao JL, Luo X, et al. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling. Int J Oncol. 2011 Feb;38(2):437-45.

Juice of fresh yu xing cao had inhibitory effect on staphylococcus aureus. yu xing cao decoction had inhibitory effect various Gram positive and negative bacteria including on staphylococcus aureus, staphylococcus albus, hemolytic streptococcus, diplococcus pneumoniae, bacilius diphtheriae, bacillus proteus, shigella dysenteriae, shigella flexneri and shigella sonnei, etc.. A yellowish oily stuff extracted from yu xing cao had inhibitory effect on various microorganism.
Effects on immune system

Yu Xing Cao
yu xin cao decoction could significantly improve the phagocytosis of human WBC in peripheral blood to staphylococcus aureus. Yu Xing Cao Injection could obviously improve the proportion of T lymphocytes in peripheral blood, and increase the phagocytosis of neutrophil leucocyte

Antileukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb.

To evaluate the anti-leukemic activity of Bidens pilosa L. var. minor (Blume) Sherff and Houttuynia cordata Thunb., cytotoxicity tests with an XTT-based colorimetric assay were used. Five leukemic cell lines, namely L1210, U937, K562, Raji and P3HR1, were cultured with hot water extracts of B. pilosa var. minor or H. cordata. Hot water extracts of B. pilosa var. minor inhibited these five leukemic cells with IC50s between 145 microg/ml and 586 microg/ml. The effect was greatest on four cell lines, namely L1210, P3MR1, Raji and K562, with IC50s below 200 microg/ml and a selective index of more than 5. Hot water extract of H. cordata inhibited these five leukemic cells with IC50s between 478 microg/ml and 662 microg/ml. The selective index was between 1.5 and 2.1. B. pilosa var. minor was more effective than H. cordata in inhibiting most of the leukemic cells in our study. We suggest that B. pilosa L. var. minor (Blume) Sherff may prove to be a useful medicinal plant for treating leukemia.
–Chang JS, Chiang LC, Chen CC, Liu LT, Wang KC, Lin CC. Am J Chin Med. 2001;29(2):303-12.

Lung cancer
Bai He Gu Jin Wan plus yu xing cao, bai hua she she cao and ban zhi lian was used as the basic formula to treat 38 cases of metaphase lung cancer, one dose every day, 22 cases were improved.

yu xing cao 30g, jie geng 15g were decocted with water to 200ml, 30ml, 3~4 times daily. 28 cases of pneumnia were treated, and 25 were cured.

Acute hepatitis with jaundice
yu xing cao 180g, white sugar 30g, water decoction, 1 dose daily for consecutive 5~10 doses. 20 cases of acute hepatitis with jaundice were treated and all were cured.
Acute bacillary dysentery

Oral administration of Kang Jun Mixture (feng wei cao, yu xing cao, wu bei zi), 50ml, tid. 153 cases of acute bacillary dysentery were treated, 57 were cured, 70 markedly effective and 20 improved.

Fresh yu xing cao was smashed to apply to affected area of mumps, bid. 16 cases of mumps were treated, and 13 were cured, 3 effective.

xi ye xiang cha cai 20g, yu xing cao 16g, water decoction, or made into tablets, 3~4 tablets, tid was used to treat 660 cases of fever in common cold. Results: 413 cases were cured, 235 markedly effective and 12 ineffective.


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